Dimethylamine, hydrochloride → HCID 67363002, compound

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Reaction Steps

A mixture of (4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-acetic acid (10.0 mg, 0.0231 mmol), dimethylamine hydrochloride (9.41 mg, 0.115 mmol), TBTU (14.8 mg, 0.0462 mmol), DIPEA (0.021 mL, 0.115 mmol) and DCM (3 mL) was stirred at rt for 30 min. The solution was concentrated in vacuo, redissolved in MeOH and purified via HPLC. The fractions containing the pure product were concentrated in vacuo to afford the title compound as a white solid. 1H NMR (400 MHz, CD3OD): δ=1.89 (d, J=7.1 Hz, 3 H), 2.99 (s, 3 H), 3.14 (s, 3 H), 5.16 (s, 2 H), 5.29 (q, J=7.3 Hz, 1 H), 7.13-7.23 (m, 1 H), 7.38 (d, J=1.3 Hz, 1 H), 7.39-7.52 (m, 2 H), 7.63 (s, 1 H), 7.81 (s, 1 H), 8.34 (d, J=1.8 Hz, 1 H). MS (ES+): m/z 460.02 (100) [MH+]. HPLC: tR=3.26 min (ZQ3, polar—5 min).

Provenance & Evidence