反应详情

To the solution of 1-(2,4-dichloro-6-(2-(isopropylsulfonyl)phenylamino)pyrimidin-5-yl)ethanol (580 mg, 1.49 mmol) in DCM (30 mL) was added PDC (561 mg, 1.49 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered through a pad of silica gel, and the pad was washed by 1 L of DCM. The filtrate was concentrated in vacuo to afford 1-(2,4-dichloro-6-(2-(isopropylsulfonyl)phenylamino)pyrimidin-5-yl)ethanone as a pale yellow solid. MS (ES+): 388.0 (MH+).

1. filtrationThe reaction mixture was filtered through a pad of silica gel
2. washthe pad was washed by 1 L of DCM
3. concentrationThe filtrate was concentrated in vacuo