HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2,5-dichloro-N-(2-(difluoromethylsulfonyl)phenyl)-pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | 2-Difluoromethanesulfonylaniline | HCID 710593 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,5-dichloro-N-(2-(difluoromethylsulfonyl)phenyl)-pyrimidin-4-amine | HCID 58290897 | — |
Reaction Steps
To a solution of 2,4,5-trichloropyrimidine (1 mmol) and 2-(difluoromethylsulfonyl)aniline (1 mmol) in 10 mL of DMF was added sodium hydride (2 mmol) at 0° C. After the reaction mixture was warmed to room temperature and stirred at 50° C. for 1 hour. After work-up and flash chromatography (CH2Cl2/MeOH 9:1), product was obtained. MS (ES+): 353.96 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592432B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-8f7e921ecd4145e88800096676bf96c5 |
| Source note | uspto-grants-2013_11 |