Isopropanol → HCID 45480464, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-4-fluoro-5-nitro-benzoic acid (5.0 g, 22.8 mmol) and cesium carbonate (29.7 g, 91.1 mmol) in 2-propanol (100 mL) was heated at 50° C. overnight. The solvent was removed in vacuo and 100 mL of water was added. Concentrated aqueous HCl was added dropwise to this solution at 0° C. until the pH is 2. The product precipitate which formed was isolated by filtration, washed by water and dried under vacuum to give 2-chloro-4-isopropoxy-5-nitro-benzoic acid.

Provenance & Evidence