Dimethylformamide → HCID 44467612, compound

Participants

Reaction Steps

To a solution of 6-(5-chloro-4-(2-(isopropylsulfonyl)phenylamino)-pyrimidin-2-ylamino)-5-isopropoxy-2-(piperidin-4-yl)isoindolin-1-one (20 mg, 0.03 mmol) in DMF (1.0 mL) was added 2-(dimethylamion)acetyl chloride hydrochloride (0.17 mmol, 26 mg) and triethyl amine (0.18 mmol, 18 mg). The reaction mixture was stirred at room temperature 1 h and the solid byproduct was removed by filtration. The remaining filtrate was purified by preparative RP-HPLC to afford 6-(5-chloro-4-(2-(isopropylsulfonyl)-phenylamino)pyrimidin-2-ylamino)-2-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-5-isopropoxyisoindolin-1-one.

Provenance & Evidence