Methyl iodide → HCID 178503522, compound

HRID 2046969Notes

Reaction equation

HRID 2046969 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12.[CH3:12]I>[OH-].[Na+].O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:12])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 178518559HCID 178518559, compound

Product 1

HCID 178503522HCID 178503522, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
5 °C

Procedure

4-hydroxy-6-mercapto-pyrazolo[3,4-d]pyrimidine (14 g) was dissolved in a solution of sodium hydroxide (10 g) in water (300 mL). The solution was cooled to 5° C. and shaken with of methyl iodide (12 g). After 15-20 minutes the solution was charcoaled, filtered and acidified with acetic acid to yield crude product. Re-crystallization in acid gave the desired product MS (ES+): 183.0 (M+1)+.

Workup

  1. filtrationfiltered
  2. customto yield crude product

Sources & evidence

ORD record
ord-9fa22ab145f44a6e8e4789609f61c6eb
Source dataset
uspto-grants-2013_11
Patent number
US08592432B2

Reaction notes

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