HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2046971Generated: October 30, 2026
Triethylamine → 2-(dimethylamino)-1-(4-(5-isopropoxy-4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-methylphenyl)piperidin-1-yl)ethanone
https://huagongshe.com/reaction/2046971
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Dimethylamino)acetyl chloride hydrochloride | HCID 13994991 | — |
| Reactant | HCID 25160548 | HCID 25160548 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(dimethylamino)-1-(4-(5-isopropoxy-4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-methylphenyl)piperidin-1-yl)ethanone | HCID 44467753 | — |
Reaction Steps
N6-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (56 mg) was dissolved in 3 mL of dichloromethane. The solution was cooled to 5° C. and 2-(dimethylamino)acetyl chloride hydrochloride (24 mg) was added to the solution followed by triethylamine (15 mg). The solution was stirred at room temperature for approximately 30 minutes. After Prep-LC-MS, the final product is obtained. MS (ES+): 649.32 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592432B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-631903b331d149d886505859209a2c01 |
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| Source note | uspto-grants-2013_11 |
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