Triethylamine → HCID 178428326, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of N6-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (20 mg, 0.035 mmol), 2-bromoethanol (0.1 N in DMF, 0.070 mmol, 0.70 mL) and triethylamine (0.1 N in DMF, 0.18 mmol, 1.75 mL) was heated at 100° C. for 10 min. The resulting reaction mixture was purified by RP-HPLC to afford 2-(4-(5-isopropoxy-4-(4-(2-(isopropylsulfonyl)phenylamino)-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-2-methylphenyl)piperidin-1-yl)ethanol. MS (ES+): 622.3 (MH+).

Provenance & Evidence