Triethylamine → HCID 178434477, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of N6-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (26.6 mg, 0.046 mmol), 1-bromo-2-methoxyethane (1.0 N in DMF, 0.46 mmol, 0.46 mL), and triethylamine (1.0 N in DMF, 0.46 mmol, 0.46 mL) was heated at 100° C. for 10 min The resulting reaction mixture was purified by RP-HPLC to afford N6-(2-isopropoxy-4-(1-methoxyethyl)piperidin-4-yl)-5-methylphenyl)-N4-(2-(isopropylsulfonyl)phenyl)-3-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine. MS (ES+): 636.3 (MH+).

Provenance & Evidence