HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 58290847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | HCID 58290898 | HCID 58290898 | — |
| Reactant | 2-Isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline | HCID 59764370 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 58290847 | HCID 58290847 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a solution of 2,4-dichloro-6-(2-(isopropylsulfonyl)phenylamino)pyrimidine-5-carbonitrile (0.5 mmol) and 2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline (0.5 mmol) in 3 mL of isopropanol, was added 4-methylbenzenesulfonic acid (0.5 mmol). The suspension was stirred at 120° C. for 2 hours. Product was obtained after work-up and prep-HPLC. MS (ES+): 597.23 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592432B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0c726ddbb4774cd4ba7aa1c05e53c0fe |
| Source note | uspto-grants-2013_11 |