HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → N2-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)-N6-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purine-2,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purin-6-amine | HCID 58290880 | — |
| Reactant | 2-Isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline | HCID 59764370 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N2-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)-N6-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purine-2,6-diamine | HCID 58290896 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
To a suspension of 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purin-6-amine (1 equivalent) in isopropanol, was added 2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline (1 equivalent) and 4-methylbenzenesulfonic acid (1 equivalent). The suspension was stirred at 150° C. for 3 hours, cooled to room temperature and the solvent evaporated. The residue was purified using a preparative HPLC to afford the desired product as a gummy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592432B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-8329caf415e346039efed7822a46eeb6 |
| Source note | uspto-grants-2013_11 |