HCID 66733609, compound → HCID 178450660, compound

Participants

Reaction Conditions

Reaction Steps

Di-tert-butyl 5-(3-ethoxy-3-oxopropanoyl)piperidine-1,2-dicarboxylate (18.79 mmol, 7.5 g) and 3-amino-1H-pyrazole (15.0 mmol, 1.25 g) were mixed and heated neat at 100° C. for 16 hours. The resulting residue is dissolved in dichloromethane (100 mL) and concentrated in vacuo to remove water formed during cyclization. LC-MS: 419 [M+H]. This solid is taken forward without further purification.

Provenance & Evidence