HCID 67494680, compound → HCID 178497545, compound

HRID 2047015Notes

Reaction equation

HRID 2047015 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11](=O)[CH2:12][C:13]([O:15]CC)=O)[CH2:7][CH2:6]1)=[O:4].[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>ClCCl>[CH3:1][O:2][C:3]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:12]=[C:13]([OH:15])[N:21]3[N:22]=[CH:23][CH:24]=[C:20]3[N:19]=2)[CH2:9][CH2:10]1)=[O:4]

Participants

4

Reactant 2

HCID 67494680HCID 67494680, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178497545HCID 178497545, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
100 °C

Procedure

4-(2-Ethoxycarbonyl-acetyl)-cyclohexanecarboxylic acid methyl ester (8.5 g) and 3-amino-1H-pyrazole (26.5 mmol, 2.2 g) were mixed and heated neat at 100° C. for 16 hours. The resulting residue is dissolved in dichloromethane (100 mL) and concentrated in vacuo to remove water formed during cyclization. This solid is taken forward without further purification. LC-MS: 403 [M+H].

Workup

  1. concentrationconcentrated in vacuo
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid is taken forward without further purification

Sources & evidence

ORD record
ord-c252108c2c4d4684825c38a86395462c
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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