Ammonia → HCID 66733907, compound

HRID 2047017Notes

Reaction equation

HRID 2047017 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[C:15](Cl)[N:14]3[N:18]=[CH:19][CH:20]=[C:13]3[N:12]=2)[CH2:7][CH2:6]1)=[O:4].[NH3:21]>CO>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[C:15]([NH2:21])[N:14]3[N:18]=[CH:19][CH:20]=[C:13]3[N:12]=2)[CH2:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86664779HCID 86664779, compound

Product 1

HCID 66733907HCID 66733907, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

4-(7-Chloro-pyrazolo[1,5-a]pyrimidin-5-yl)-cyclohexanecarboxylic acid methyl ester (2.5 g, 8.51 mmol) was dissolved in 15 mL ˜7N ammonia in methanol in a sealed vessel. The reaction mixture was heated at 80° C. for 16 hours. After 16 hours, the reaction mixture is cooled to room temperature and concentrated in vacuo to yield a brown solid (2.58 g). The title compound was used in the next step without further purification. LC-MS: 275 [M+H].

Workup

  1. temperaturethe reaction mixture is cooled to room temperature
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-32fa7b7bf90546678968ad45621e159b
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

Loading…