Trifluoroacetic acid water → HCID 67494455, compound

Participants

Reaction Steps

The crude, 6-bromo-5-(4-(methylsulfonyl)phenoxy)-3-(quinolin-3-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine from above step E was treated with 50% TFA/H2O (3 mL) and stirred at room temperature for 1 h. Solvent was removed to yield thick oil which was purified by prep HPLC to give the final product. 6-bromo-5-(4-(methylsulfonyl)phenoxy)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine. HPLC-MS tR=1.37 min (UV254 nm); mass calculated for formula C22H16BrN5O3S2 509.0, observed LCMS m/z 510.0 (M+H).

Provenance & Evidence