Diethyl (cyanomethyl)phosphonate → HCID 66739719, compound

HRID 2047058Notes

Reaction equation

HRID 2047058 reaction equation
[CH3:1][Si:2]([CH3:38])([CH3:37])[CH2:3][CH2:4][O:5][CH2:6][N:7]([CH2:29][O:30][CH2:31][CH2:32][Si:33]([CH3:36])([CH3:35])[CH3:34])[C:8]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[N:11]=[C:10]([CH:17]2[CH2:22][CH2:21][C:20](=[CH:23][C:24](OCC)=O)[CH2:19][CH2:18]2)[CH:9]=1.C(CP(=O)(OCC)OCC)#[N:40]>>[CH3:36][Si:33]([CH3:34])([CH3:35])[CH2:32][CH2:31][O:30][CH2:29][N:7]([CH2:6][O:5][CH2:4][CH2:3][Si:2]([CH3:38])([CH3:37])[CH3:1])[C:8]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[N:11]=[C:10]([CH:17]2[CH2:18][CH2:19][C:20](=[CH:23][C:24]#[N:40])[CH2:21][CH2:22]2)[CH:9]=1

Participants

3

Reactant 2

HCID 75676Diethyl (cyanomethyl)phosphonateHCID 66733552Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate

Product 1

HCID 66739719HCID 66739719, compound

Procedure

2-(4-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetonitrile was synthesized in a manner similar to the synthesis of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate, but with diethyl cyanomethylphosphonate substituted for triethyl phosphonoacetate.

Sources & evidence

ORD record
ord-40f22c873b754631b18e2f0c0faafc5e
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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