Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate → 1,4-Dioxaspiro[4.5]decane-7-carboxylic acid

HRID 2047083Notes

Reaction equation

HRID 2047083 reaction equation
O1C2(CCC(C(O)=O)CC2)OCC1.[O:14]1[C:18]2([CH2:23][CH2:22][CH2:21][CH:20]([C:24]([O:26]CC)=[O:25])[CH2:19]2)[O:17][CH2:16][CH2:15]1.O1C2(CCC(C(OCC)=O)CC2)OCC1>>[O:14]1[C:18]2([CH2:23][CH2:22][CH2:21][CH:20]([C:24]([OH:26])=[O:25])[CH2:19]2)[O:17][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 10488810Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylateHCID 117453341,4-Dioxaspiro[4.5]decane-8-carboxylic acidHCID 597318471,4-Dioxa-spiro[4.5]decane-7-carboxylic acid ethyl ester

Product 1

HCID 5674921,4-Dioxaspiro[4.5]decane-7-carboxylic acid

Procedure

1,4-Dioxaspiro[4.5]decane-7-carboxylic acid was synthesized in a manner similar to the synthesis of 1,4-dioxaspiro[4.5]decane-8-carboxylic acid, but with ethyl 1,4-dioxaspiro[4.5]decane-7-carboxylate substituted for ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate.

Sources & evidence

ORD record
ord-aa4168b503574bbea33a6113d420ad48
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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