Ethyl 1,4-dioxaspiro[4.4]nonane-7-carboxylate → 1,4-Dioxaspiro[4.4]nonane-7-carboxylic acid

HRID 2047084Notes

Reaction equation

HRID 2047084 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]([OH:13])=[O:12])[CH2:7]C2)[O:4][CH2:3][CH2:2]1.O1C2(CCC(C(OCC)=O)C2)OCC1.O1C2(CCC(C(OCC)=O)CC2)OCC1>>[O:4]1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]([OH:13])=[O:12])[CH2:7]2)[O:1][CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 245433Ethyl 1,4-dioxaspiro[4.4]nonane-7-carboxylateHCID 10488810Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylateHCID 117453341,4-Dioxaspiro[4.5]decane-8-carboxylic acid

Product 1

HCID 214672221,4-Dioxaspiro[4.4]nonane-7-carboxylic acid

Procedure

1,4-dioxaspiro[4.4]nonane-7-carboxylic acid was synthesized in a manner similar to the synthesis of 1,4-dioxaspiro[4.5]decane-8-carboxylic acid, but with ethyl 1,4-dioxaspiro[4.4]nonane-7-carboxylate substituted for ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate.

Sources & evidence

ORD record
ord-7731dbfac57341b5be2c0b772079d121
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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