1,4-Dioxaspiro[4.5]decane-7-carboxylic acid → Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-7-yl)propanoate

HRID 2047085Notes

Reaction equation

HRID 2047085 reaction equation
O=C(C1CCC2(OCCO2)CC1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[O:19]1[C:23]2([CH2:28][CH2:27][CH2:26][CH:25]([C:29]([OH:31])=O)[CH2:24]2)[O:22][CH2:21][CH2:20]1.O1C2(CCC(C(O)=O)CC2)OCC1>>[O:31]=[C:29]([CH:25]1[CH2:26][CH2:27][CH2:28][C:23]2([O:19][CH2:20][CH2:21][O:22]2)[CH2:24]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 3

HCID 5674921,4-Dioxaspiro[4.5]decane-7-carboxylic acidHCID 117453341,4-Dioxaspiro[4.5]decane-8-carboxylic acidHCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate

Product 1

HCID 66733612Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-7-yl)propanoate

Procedure

Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-7-yl)propanoate was synthesized in a manner similar to the synthesis of ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate, but with 1,4-dioxaspiro[4.5]decane-7-carboxylic acid substituted for 1,4-dioxaspiro[4.5]decane-8-carboxylic acid.

Sources & evidence

ORD record
ord-932c39397fbf4f88b8aecb9f44de282b
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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