1,4-Dioxaspiro[4.5]decane-8-carboxylic acid → Ethyl 3-oxo-3-(1,4-dioxaspiro[4.4]nonan-7-yl)propanoate

HRID 2047086Notes

Reaction equation

HRID 2047086 reaction equation
[O:1]=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11]C1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].O1C2(CCC(C(O)=O)C2)OCC1.O1C2(CCC(C(O)=O)CC2)OCC1>>[O:1]=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:13][CH2:14][CH2:15][O:16]2)[CH2:11]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 3

HCID 117453341,4-Dioxaspiro[4.5]decane-8-carboxylic acidHCID 214672221,4-Dioxaspiro[4.4]nonane-7-carboxylic acidHCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate

Product 1

HCID 66733777Ethyl 3-oxo-3-(1,4-dioxaspiro[4.4]nonan-7-yl)propanoate

Procedure

Ethyl 3-oxo-3-(1,4-dioxaspiro[4.4]nonan-7-yl)propanoate was synthesized in a manner similar to the synthesis of ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate, but with 1,4-dioxaspiro[4.4]nonane-7-carboxylic acid substituted for 1,4-dioxaspiro[4.5]decane-8-carboxylic acid.

Sources & evidence

ORD record
ord-55887559ad824c3e8e6fcdf32c80cd66
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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