Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515483, compound

HRID 2047088Notes

Reaction equation

HRID 2047088 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[C:15]([OH:17])[N:14]4[N:18]=[CH:19][CH:20]=[C:13]4[N:12]=3)[CH2:7]C2)[O:4][CH2:3][CH2:2]1.O=C(C1CCC2(OCCO2)C1)CC(OCC)=O.O=C(C1CCC2(OCCO2)CC1)CC(OCC)=O>>[O:4]1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[C:15]([OH:17])[N:14]4[N:18]=[CH:19][CH:20]=[C:13]4[N:12]=3)[CH2:7]2)[O:1][CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 66733777Ethyl 3-oxo-3-(1,4-dioxaspiro[4.4]nonan-7-yl)propanoateHCID 178515484HCID 178515484, compound

Product 1

HCID 178515483HCID 178515483, compound

Procedure

5-(1,4-dioxaspiro[4.4]nonan-7-yl)pyrazolo[1,5-a]pyrimidin-7-ol was synthesized in a manner similar to the synthesis of 5-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-ol, but with ethyl 3-oxo-3-(1,4-dioxaspiro[4.4]nonan-7-yl)propanoate substituted for ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate.

Sources & evidence

ORD record
ord-9b9185abeaeb46198d1a0874e3ba7434
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

Loading…