5-(1,4-Dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-amine → HCID 66733391, compound

HRID 2047094Notes

Reaction equation

HRID 2047094 reaction equation
[NH2:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][CH2:15][C:14](=[O:17])[CH2:13]C2)[CH:3]=1.O1C2(CCC(C3C=C(N)N4N=CC=C4N=3)C2)OCC1.O1C2(CCC(C3C=C(N)N4N=CC=C4N=3)CC2)OCC1>>[NH2:1][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][CH2:15][C:14](=[O:17])[CH2:13]2)[CH:3]=1

Participants

4

Reactant 3

HCID 667334895-(1,4-Dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-amineHCID 66733812HCID 66733812, compoundHCID 66733850HCID 66733850, compound

Product 1

HCID 66733391HCID 66733391, compound

Procedure

3-(7-Aminopyrazolo[1,5-a]pyrimidin-5-yl)cyclopentanone was synthesized in a manner similar to the synthesis of 4-(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone, but 5-(1,4-dioxaspiro[4.4]nonan-7-yl)pyrazolo[1,5-a]pyrimidin-7-amine substituted for 5-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-amine.

Sources & evidence

ORD record
ord-d44e04248ecc42aba4a3d6bfb4193790
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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