4-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone → HCID 67494226, compound

HRID 2047095Notes

Reaction equation

HRID 2047095 reaction equation
[CH3:1][Si:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][O:5][CH2:6][N:7]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:8]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[N:11]=[C:10]([CH:17]2[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]2)[CH:9]=1.NC1N2N=CC=C2N=C(C2CCCC(=[O:50])C2)C=1.NC1N2N=CC=C2N=C(C2CCC(=O)CC2)C=1>>[CH3:30][Si:28]([CH3:29])([CH3:31])[CH2:27][CH2:26][O:25][CH2:24][N:7]([CH2:6][O:5][CH2:4][CH2:3][Si:2]([CH3:1])([CH3:33])[CH3:32])[C:8]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[N:11]=[C:10]([CH:17]2[CH2:22][CH2:21][CH2:20][C:19](=[O:50])[CH2:18]2)[CH:9]=1

Participants

4

Reactant 3

HCID 665836364-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanoneHCID 66733850HCID 66733850, compoundHCID 66738291HCID 66738291, compound

Product 1

HCID 67494226HCID 67494226, compound

Procedure

3-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone was synthesized in a manner similar to the synthesis of 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone, but 3-(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone substituted for 4-(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone.

Sources & evidence

ORD record
ord-c9e2b3df71564a05848eb5779252aac6
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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