4-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone → Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate

HRID 2047097Notes

Reaction equation

HRID 2047097 reaction equation
C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(=[CH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])CC2)C=1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCCC(=O)C2)C=1.[CH3:72][Si:73]([CH3:104])([CH3:103])[CH2:74][CH2:75][O:76][CH2:77][N:78]([CH2:95][O:96][CH2:97][CH2:98][Si:99]([CH3:102])([CH3:101])[CH3:100])[C:79]1[N:84]2[N:85]=[CH:86][CH:87]=[C:83]2[N:82]=[C:81]([CH:88]2[CH2:93][CH2:92][C:91](=O)[CH2:90][CH2:89]2)[CH:80]=1>>[CH3:101][Si:99]([CH3:100])([CH3:102])[CH2:98][CH2:97][O:96][CH2:95][N:78]([CH2:77][O:76][CH2:75][CH2:74][Si:73]([CH3:72])([CH3:103])[CH3:104])[C:79]1[N:84]2[N:85]=[CH:86][CH:87]=[C:83]2[N:82]=[C:81]([CH:88]2[CH2:93][CH2:92][CH2:91][C:90](=[CH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:89]2)[CH:80]=1

Participants

4

Reactant 3

HCID 665836364-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanoneHCID 66733552Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetateHCID 67494226HCID 67494226, compound

Product 1

HCID 67494281Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate

Procedure

Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate was synthesized in a manner similar to the synthesis of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate, but with 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone substituted for 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone.

Sources & evidence

ORD record
ord-5c797f8760654e02995aa2ae12170cbf
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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