Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate → Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

HRID 2047099Notes

Reaction equation

HRID 2047099 reaction equation
C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(CC(OCC)=O)CC2)C=1.[CH3:39][Si:40]([CH3:76])([CH3:75])[CH2:41][CH2:42][O:43][CH2:44][N:45]([CH2:67][O:68][CH2:69][CH2:70][Si:71]([CH3:74])([CH3:73])[CH3:72])[C:46]1[N:51]2[N:52]=[CH:53][CH:54]=[C:50]2[N:49]=[C:48]([CH:55]2[CH2:60][CH2:59][CH2:58][C:57](=[CH:61][C:62]([O:64][CH2:65][CH3:66])=[O:63])[CH2:56]2)[CH:47]=1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(=CC(OCC)=O)CC2)C=1>>[CH3:74][Si:71]([CH3:72])([CH3:73])[CH2:70][CH2:69][O:68][CH2:67][N:45]([CH2:44][O:43][CH2:42][CH2:41][Si:40]([CH3:76])([CH3:75])[CH3:39])[C:46]1[N:51]2[N:52]=[CH:53][CH:54]=[C:50]2[N:49]=[C:48]([CH:55]2[CH2:60][CH2:59][CH2:58][CH:57]([CH2:61][C:62]([O:64][CH2:65][CH3:66])=[O:63])[CH2:56]2)[CH:47]=1

Participants

4

Reactant 3

HCID 66733552Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetateHCID 66733619Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetateHCID 67494281Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate

Product 1

HCID 66733652Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Procedure

Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate was synthesized in a manner similar to the synthesis of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate, but with ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate substituted for ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate.

Sources & evidence

ORD record
ord-9f169476f5d84b289eabd1776a6d0d27
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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