Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate → HCID 66733795, compound

HRID 2047100Notes

Reaction equation

HRID 2047100 reaction equation
C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(CC(OCC)=O)CC2)C=1.[CH3:39][Si:40]([CH3:72])([CH3:71])[CH2:41][CH2:42][O:43][CH2:44][N:45]([CH2:63][O:64][CH2:65][CH2:66][Si:67]([CH3:70])([CH3:69])[CH3:68])[C:46]1[N:51]2[N:52]=[CH:53][CH:54]=[C:50]2[N:49]=[C:48]([CH:55]2[CH2:59][CH2:58][C:57](=[CH:60][C:61]#[N:62])[CH2:56]2)[CH:47]=1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(=CC(OCC)=O)CC2)C=1>>[CH3:71][Si:40]([CH3:39])([CH3:72])[CH2:41][CH2:42][O:43][CH2:44][N:45]([CH2:63][O:64][CH2:65][CH2:66][Si:67]([CH3:70])([CH3:69])[CH3:68])[C:46]1[N:51]2[N:52]=[CH:53][CH:54]=[C:50]2[N:49]=[C:48]([CH:55]2[CH2:59][CH2:58][CH:57]([CH2:60][C:61]#[N:62])[CH2:56]2)[CH:47]=1

Participants

4

Reactant 3

HCID 66733552Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetateHCID 66733619Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetateHCID 67494248HCID 67494248, compound

Product 1

HCID 66733795HCID 66733795, compound

Procedure

2-(3-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclopentyl)acetonitrile was synthesized in a manner similar to the synthesis of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate, but 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclopentylidene)acetonitrile substituted for ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexylidene)acetate.

Sources & evidence

ORD record
ord-fa3ab20358c5436087f880d4d42fe941
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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