HCID 66733407, compound → HCID 67494537, compound

HRID 2047102Notes

Reaction equation

HRID 2047102 reaction equation
[CH3:1][Si:2]([CH3:39])([CH3:38])[CH2:3][CH2:4][O:5][CH2:6][N:7]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[C:8]1[N:13]2[N:14]=[CH:15][C:16]([I:17])=[C:12]2[N:11]=[C:10]([CH:18]2[CH2:23]C[CH:21]([CH2:24][C:25](OCC)=O)[CH2:20][CH2:19]2)[CH:9]=1.C[Si](C)(C)CCOC[N:46](COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCCC(CC(OCC)=O)C2)C=1.C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)C1N2N=CC=C2N=C(C2CCC(CC(OCC)=O)CC2)C=1>>[CH3:38][Si:2]([CH3:1])([CH3:39])[CH2:3][CH2:4][O:5][CH2:6][N:7]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[C:8]1[N:13]2[N:14]=[CH:15][C:16]([I:17])=[C:12]2[N:11]=[C:10]([CH:18]2[CH2:19][CH2:20][CH:21]([CH2:24][C:25]#[N:46])[CH2:23]2)[CH:9]=1

Participants

4

Reactant 3

HCID 66733407HCID 66733407, compoundHCID 66733619Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)-methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetateHCID 66733652Ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

Product 1

HCID 67494537HCID 67494537, compound

Procedure

2-(3-(7-(Bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)cyclopentyl)acetonitrile was synthesized in a manner similar to the synthesis of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate, but with ethyl 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate substituted for ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate.

Sources & evidence

ORD record
ord-883347d58202441196439733b93dffe0
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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