tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate → HCID 178451769, compound

HRID 2047108Notes

Reaction equation

HRID 2047108 reaction equation
O1C2([CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[C:15]([OH:17])[N:14]4[N:18]=[CH:19][CH:20]=[C:13]4[N:12]=3)[CH2:7][CH2:6]2)OCC1.C(OC(=O)CC(C1CC[N:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])CC1)=O)C.O=C(C1CCC2(OCCO2)CC1)CC(OCC)=O>>[OH:17][C:15]1[N:14]2[N:18]=[CH:19][CH:20]=[C:13]2[N:12]=[C:11]([CH:8]2[CH2:7][CH2:6][N:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:10][CH2:9]2)[CH:16]=1

Participants

4

Reactant 3

HCID 6618868tert-Butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylateHCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 178515484HCID 178515484, compound

Product 1

HCID 178451769HCID 178451769, compound

Procedure

tert-Butyl 4-(7-hydroxypyrazolo[1,5-a]pyrimidin-5-yl)piperidine-1-carboxylate was synthesized in a manner similar to the synthesis of 5-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazolo[1,5-a]pyrimidin-7-ol, but with tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate substituted for ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate.

Sources & evidence

ORD record
ord-59073fca3fac40d7880f98ee1b34baee
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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