Ammonia → HCID 67494457, compound

HRID 2047120Notes

Reaction equation

HRID 2047120 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12]2)[CH:3]=1.[NH3:23]>CO>[NH2:23][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12]2)[CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86664785HCID 86664785, compound

Product 1

HCID 67494457HCID 67494457, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of tert-butyl 3-(7-chloropyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine-1-carboxylate (3.40 g, 10.5 mmol) in a solution of ammonia in MeOH (7N, 20 mL) was heated in sealed vessel at 80° C. for 5 h. The reaction mixture was cooled down and concentrated in vacuo. The residue was dried in high vacuum and used for the next step without further purification. LC/MS RT=1.30 min (5 min method). Mass calculated for, M+H 303.17, observed 318.19.

Workup

  1. temperatureThe reaction mixture was cooled down
  2. concentrationconcentrated in vacuo
  3. customThe residue was dried in high vacuum
  4. customused for the next step without further purification
  5. customLC/MS RT=1.30 min (5 min method)

Sources & evidence

ORD record
ord-7712668edcf44ec193221eb78ef7aa2c
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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