Ethanol → HCID 46945343, compound

Participants

Reaction Conditions

Reaction Steps

To crude 5-(morpholinomethyl)-3-(quinolin-3-yl)-N,N-bis((2-(trimethylsilyl)-ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine (0.2 g) in a 20 mL vial was added EtOH (4 mL) and then 4M HCl/dioxane (1.5 mL, 6.0 mmol). The vial was capped and heated at 85° C. for 16 hours. On cooling, saturated NaHCO3 solution (˜0.5 mL) was added, and the reaction mixture was stirred for 30 minutes. The reaction mixture was then transferred to a separatory funnel using CH2Cl2 (20 mL) and H2O (20 mL) and saturated NaHCO3 solution (20 mL) and brine (20 mL) were added. Organics were extracted with CH2Cl2 (4×30 mL), dried (Na2SO4) and concentrated in vacuo to give crude 5-(morpholinomethyl)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine as a brown solid (0.04 g). LCMS: 0.78 mins, m/z=361.1 (MH+).

Provenance & Evidence