Sodium Bicarbonate → HCID 67494427, compound

Participants

Reaction Steps

A mixture of tert-butyl 1-(methylthiomethyl)cyclopropylcarbamate (crude), Oxone (4.8 g, 7.8 mmol) and NaHCO3 (2.6 g, 31.3 mmol) in MeOH (28 ml) and Water (7 ml) was stirred at room temperature for 1.5 h, at which time LC/MS analysis confirmed full consumption of starting material. Solvent was removed in vacuo and the crude was redissolved in EtOAc (100 ml), washed with water (1×20 ml), brine (1×20 ml), dried over MgSO4. Solvent was removed in vacuo to give tert-butyl 1-(methylsulfonylmethyl)cyclopropylcarbamate as a crude product (white solid, 1.1 g) which was used for the next step without any purification.

Provenance & Evidence