Acetic Anhydride → HCID 68153023, compound

Participants

Reaction Conditions

Reaction Steps

The intermediate N-(3-(4-(4-(2-acetylhydrazinecarbonyl)-3-(2-chloro-6-fluorophenyl) isoxazol-5-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide (25.0 mg, 0.044 mmol) was dissolved in acetic acid (1.50 mL). Acetic anhydride (104 μL, 1.1 mmol) was added and the reaction mixture was heated in the microwave to 140° C. for 8 h. The reaction mixture was diluted with water (40 mL) and extracted with CH2Cl2 (3×20 mL). The combined organic layers were washed with water (10 mL), dried over Na2SO4 and concentrated in vacuo.

Provenance & Evidence