HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylethylamine → 2-Ethyl-6-(ethyl-methyl-amino)-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylethylamine | HCID 12219 | — |
| Reactant | 2,6-Dichloroisonicotinic acid | HCID 94830 | — |
| Reactant | 2-(Diethylamino)-6-methylisonicotinic acid | HCID 58418055 | — |
| Product | 2-Ethyl-6-(ethyl-methyl-amino)-isonicotinic acid | HCID 58418016 | — |
Reaction Steps
The title compound is prepared in analogy to 2-diethylamino-6-methyl-isonicotinic acid starting from 2,6-dichloro-isonicotinic acid and N-ethyl-N-methylamine; LC-MS: tR=0.56 min, [M+1]+=209.09; 1H NMR (D6-DMSO): δ 1.16 (t, J=7.0 Hz, 3H), 1.24 (t, J=7.3 Hz, 3H), 2.95 (q, J=7.5 Hz, 2H), 3.57 (s, 3H), 3.76 (q, J=6.8 Hz, 2H), 6.98 (s, 1H), 7.23 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592460B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-76ab51ef58c34a66a115381c687b3e70 |
| Source note | uspto-grants-2013_11 |