N-Methylisobutylamine → 2-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

HRID 2047280Notes

Reaction equation

HRID 2047280 reaction equation
[CH2:1](N(CC)C1C=C(C=C(C)N=1)C(O)=O)C.Cl[C:17]1[CH:18]=[C:19]([CH:23]=[C:24](Cl)[N:25]=1)[C:20]([OH:22])=[O:21].[CH2:27]([NH:31][CH3:32])[CH:28]([CH3:30])[CH3:29]>>[CH2:27]([N:31]([CH3:32])[C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([CH3:1])[N:25]=1)[C:20]([OH:22])=[O:21])[CH:28]([CH3:30])[CH3:29]

Participants

4

Reactant 3

HCID 12249N-MethylisobutylamineHCID 948302,6-Dichloroisonicotinic acidHCID 584180552-(Diethylamino)-6-methylisonicotinic acid

Product 1

HCID 584180962-(Isobutyl-methyl-amino)-6-methyl-isonicotinic acid

Procedure

The title compound is prepared in analogy to 2-diethylamino-6-methyl-isonicotinic acid starting from 2,6-dichloro-isonicotinic acid and N-isobutyl-N-methylamine; LC-MS: tR=0.50*min, [M+1]+=223.28.

Sources & evidence

ORD record
ord-54bd1373234d47c6bf6c87bee51fde5d
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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