2-Methyl-6-propylphenol → HCID 178439252, compound

HRID 2047287Notes

Reaction equation

HRID 2047287 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][CH3:10])[C:3]=1[OH:11].C(C1C=C(C=C(C)C=1O)[C:17]([NH:19][OH:20])=[NH:18])C>>[OH:11][C:3]1[C:4]([CH2:8][CH2:9][CH3:10])=[CH:5][C:6]([C:17]([NH:19][OH:20])=[NH:18])=[CH:7][C:2]=1[CH3:1]

Participants

3

Reactant 2

HCID 2484752-Methyl-6-propylphenolHCID 178436626HCID 178436626, compound

Product 1

HCID 178439252HCID 178439252, compound

Procedure

The title compound is prepared from commercially available 2-methyl-6-propyl-phenol in analogy to literature procedures (e.g. B. Roth et al. J. Med. Chem. 31 (1988) 122-129; and literature cited for 3-ethyl-4,N-dihydroxy-5-methyl-benzamidine); LC-MS: tR=0.54 min; [M+1]+=209.43; 1H NMR (D6-DMSO): δ 0.90 (t, J=7.3 Hz, 3H), 1.48-1.59 (m, 3H), 2.19 (s, 3H), 2.56 (t, J=7.3 Hz, 2H), 7.37 (s, 1H), 7.40 (s, 1H), 9.34 (s, 1H).

Sources & evidence

ORD record
ord-6b739b73110b41549e00815d43fa1641
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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