4-(2-Hydroxyethyl)benzonitrile → CID 59604233

HRID 2047301Notes

Reaction equation

HRID 2047301 reaction equation
C(OC(=O)[CH2:7][CH2:8][C:9]1[C:14](C)=[CH:13][C:12]([C:16](=[NH:19])[NH:17][OH:18])=[CH:11][C:10]=1C)(C)(C)C.[OH:22]CCC1C=CC(C#N)=CC=1>>[OH:18][NH:17][C:16](=[NH:19])[C:12]1[CH:13]=[CH:14][C:9]([CH2:8][CH2:7][OH:22])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 28008154-(2-Hydroxyethyl)benzonitrileHCID 178426653HCID 178426653, compound

Product 1

HCID 59604233CID 59604233

Procedure

The title compound is prepared in analogy to 3-[4-(N-hydroxycarbamimidoyl)-2,6-dimethyl-phenyl]-propionic acid tert-butyl ester (step g) starting from 4-(2-hydroxy-ethyl)-benzonitrile; LC-MS: tR=0.50*min, [M+1]+=181.27.

Sources & evidence

ORD record
ord-d3f331cb447d4250b566600cb8549a61
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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