4-Propoxybenzonitrile → N-Hydroxy-4-propoxy-benzamidine

HRID 2047302Notes

Reaction equation

HRID 2047302 reaction equation
C(OC(=O)CC[C:9]1[C:14](C)=[CH:13][C:12]([C:16](=[NH:19])[NH:17][OH:18])=[CH:11][C:10]=1C)(C)(C)C.[CH2:22]([O:25]C1C=CC(C#N)=CC=1)[CH2:23][CH3:24]>>[OH:18][NH:17][C:16](=[NH:19])[C:12]1[CH:11]=[CH:10][C:9]([O:25][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 3229394-PropoxybenzonitrileHCID 178426653HCID 178426653, compound

Product 1

HCID 178458440N-Hydroxy-4-propoxy-benzamidine

Procedure

The title compound is prepared in analogy to 3-[4-(N-hydroxycarbamimidoyl)-2,6-dimethyl-phenyl]-propionic acid tert-butyl ester (step g) starting from 4-propoxy-benzonitrile; LC-MS: tR=0.71*min, [M+1]+=195.28.

Sources & evidence

ORD record
ord-9574a61e822c4dcb8dc7b77dfcd63820
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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