alpha-Chlorohydrin, (+)- → HCID 25074251, compound

HRID 2047311Notes

Reaction equation

HRID 2047311 reaction equation
[CH2:1]([N:3]([CH3:30])[C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:26]=[C:25]([CH3:27])[C:18]([O:19][CH2:20][C@H:21]([OH:24])[CH2:22][OH:23])=[C:17]([CH3:28])[CH:16]=3)[N:11]=2)[CH:7]=[C:6]([CH3:29])[N:5]=1)[CH3:2].ClC[C@@H](O)CO>>[CH2:1]([N:3]([CH3:30])[C:4]1[CH:9]=[C:8]([C:10]2[O:14][N:13]=[C:12]([C:15]3[CH:26]=[C:25]([CH3:27])[C:18]([O:19][CH2:20][C@@H:21]([OH:24])[CH2:22][OH:23])=[C:17]([CH3:28])[CH:16]=3)[N:11]=2)[CH:7]=[C:6]([CH3:29])[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 148904alpha-Chlorohydrin, (+)-HCID 25074250HCID 25074250, compound

Product 1

HCID 25074251HCID 25074251, compound

Procedure

(S)-3-(4-{5-[2-(ethyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2,6-dimethyl-phenoxy)-propane-1,2-diol is prepared in analogy to (R)-3-(4-{5-[2-(ethyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2,6-dimethyl-phenoxy)-propane-1,2-diol using (S)-3-chloro-1,2-propanediol; LC-MS: tR=0.75 min; [M+1]+=413.18.

Sources & evidence

ORD record
ord-2d080f0bbfad47a5b1408319005646b7
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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