HCID 25069533, compound → HCID 25074253, compound

Participants

Reaction Steps

N-(3-{4-[5-(2-Diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-(S)-2-hydroxy-propyl)-2-hydroxy-acetamide is prepared in analogy to N-(3-{4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-(R)-2-hydroxy-propyl)-2-hydroxy-acetamide starting from (S)-1-amino-3-{4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propan-2-ol; LC-MS: tR=0.78 min; [M+1]+=498.20; 1H NMR (CDCl3): δ 1.24 (t, J=7.0 Hz, 6H), 1.32 (t, J=7.3 Hz, 3H), 2.39 (s, 3H), 2.49 (s, 3H), 2.75 (q, J=7.5 Hz, 2H), 2.83 (s br, 1H), 3.44 (s br, 1H), 3.48-3.57 (m, 1H), 3.62 (q, J=6.8 Hz, 4H), 3.75-3.94 (m, 3H), 4.17-4.25 (m, 3H), 7.00 (s, 1H), 7.05 (t, J=4.5 Hz, 1H), 7.09 (s, 1H), 7.87 (s, 1H), 7.88 (s, 1H).

Provenance & Evidence