alpha-Chlorohydrin, (+)- → HCID 25074252, compound

HRID 2047318Notes

Reaction equation

HRID 2047318 reaction equation
[CH:1]([N:4]([CH3:26])[C:5]1[CH:10]=[C:9]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:21]=[C:20]([CH3:22])[C:19]([OH:23])=[C:18]([CH3:24])[CH:17]=3)[N:12]=2)[CH:8]=[C:7]([CH3:25])[N:6]=1)([CH3:3])[CH3:2].Cl[CH2:28][C@@H:29]([OH:32])[CH2:30][OH:31]>>[CH:1]([N:4]([CH3:26])[C:5]1[CH:10]=[C:9]([C:11]2[O:15][N:14]=[C:13]([C:16]3[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH2:28][C@@H:29]([OH:32])[CH2:30][OH:31])=[C:18]([CH3:24])[CH:17]=3)[N:12]=2)[CH:8]=[C:7]([CH3:25])[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 148904alpha-Chlorohydrin, (+)-HCID 135955184HCID 135955184, compound

Product 1

HCID 25074252HCID 25074252, compound

Procedure

(S)-3-(4-{5-[2-(Isopropyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2,6-dimethyl-phenoxy)-propane-1,2-diol is prepared in analogy to Example 3 from 4-{5-[2-(isopropyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-2,6-dimethyl-phenol using (S)-3-chloro-1,2-propanediol; LC-MS: tR=0.78 min; [M+1]+=427.08.

Sources & evidence

ORD record
ord-2ad536a0d9b041deb3938ce98762b84c
Source dataset
uspto-grants-2013_11
Patent number
US08592460B2

Reaction notes

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