alpha-Chlorohydrin, (+)- → HCID 24936207, compound

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Reaction Steps

(S)-3-(2-Ethyl-4-{5-[2-(isopropyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxa-diazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol is prepared from 2-ethyl-4-{5-[2-(isopropyl-methyl-amino)-6-methyl-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenol and (S)-3-chloro-1,2-propanediol in analogy to Example 3; LC-MS: tR=1.07 min; [M+1]+=441.37; 1H NMR (CDCl3): δ 1.24 (d, J=6.5 Hz, 6H), 1.33 (t, J=7.5 Hz, 3H), 2.05 (t, J=5.1 Hz, 1H), 2.41 (s, 3H), 2.51 (s, 3H), 2.73 (d, J=5.5 Hz, 1H), 2.78 (q, J=7.5 Hz, 2H), 2.97 (s, 3H), 3.81-4.00 (m, 4H), 4.12-4.21 (m, 1H), 4.95-5.05 (m, 1H), 7.06 (s, 1H), 7.13 (s, 1H), 7.88 (s, 1H), 7.89 (s, 1H).

Provenance & Evidence