Methylamine → HCID 68578852, compound

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Reaction Steps

A solution of crude methanesulfonic acid 2-{4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-ethyl ester (110 mg, 0.225 mmol, Example 55 step a)) in 8 M methylamine in methanol (4 mL) is stirred in a sealed glass vial at 70° C. for 15 h. The solvent is evaporated and the crude product is purified on prep. TLC plates using DCM containing 10% of 7 N NH3 in methanol to give the title compound (93 mg) as a pale yellow oil; LC-MS: tR=0.71 min; [M+1]+=424.19.

Provenance & Evidence