HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-{4-[5-(2-Diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenyl}-N-(2-hydroxy-ethyl)-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 3-{4-[5-(2-Diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenyl}-propionic acid | HCID 68578530 | — |
| Product | 3-{4-[5-(2-Diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenyl}-N-(2-hydroxy-ethyl)-propionamide | HCID 68578436 | — |
Reaction Steps
The title compound is prepared by coupling 3-{4-[5-(2-diethylamino-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenyl}-propionic acid with ethanolamine as described in Example 26 omitting the treatment with HCl; LC-MS: tR=0.80 min; [M+1]+=466.26.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592460B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c5e2a68f5d8c48a0a7b110cde63e5069 |
| Source note | uspto-grants-2013_11 |