Hydrochloric Acid → HCID 58388240, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl[5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbamate (1.3 g, 3.73 mmol) in methanol (18.66 ml) at 25° C. was added HCl (18.66 ml, 74.7 mmol)[4M in dioxane]. After 12 h, additional HCl (18.66 ml, 74.7 mmol)[4M in dioxane] was added and the solution stirred 12 h. The reaction mixture was concentrated to a dark foam affording the HCl salt of [5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thienyl]amine (1.1 g, 99% yield): LCMS (ES) m/e 248, 250 (M, M+2)+.

Provenance & Evidence