HCID 68671013, compound → (2-{4-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperazin-1-yl}-ethyl)-dimethyl-amine

HRID 2047366Notes

Reaction equation

HRID 2047366 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])[CH2:18][CH2:17]2)[CH:13]=[CH:12][C:11]=1[Cl:27]>C(O)(=O)C>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[C:10]1[CH:15]=[C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])[CH2:18][CH2:17]2)[CH:13]=[CH:12][C:11]=1[Cl:27]

Participants

3

Reactant 1

HCID 68671013HCID 68671013, compound

Product 1

HCID 42622923(2-{4-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperazin-1-yl}-ethyl)-dimethyl-amineYield 75%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of N-(2-amino-phenyl)-2-chloro-5-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-benzamide (0.35 g, 0.87 mmol) in acetic acid (15 mL) was heated for 7 h at 85° C., then solvent was removed under reduced pressure and the residue triturated with Et2O to obtain 0.25 g (75%) of the title compound as a solid without further purification.

Workup

  1. customsolvent was removed under reduced pressure
  2. customthe residue triturated with Et2O

Sources & evidence

ORD record
ord-f4fb6826daff4bdcac0f706304c1915b
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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