Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 1-[3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl]piperidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 8-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-1,4-dioxa-8-aza-spiro[4.5]decane | HCID 59568063 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-[3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl]piperidin-4-one | HCID 59568243 | 90.6% |
반응 단계
To a suspension of 8-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-1,4-dioxa-8-aza-spiro[4.5]decane (2.00 g, 5.42 mmol) in water (50 mL) was added H2SO4 (2.50 mL) dropwise and the resulting solution was stirred for 72 h at room temperature. The solution was neutralized with Na2CO3 and the oil obtained solidified on standing in water. The precipitate was filtered and dried to obtain 1.60 g (90%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08592463B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-565b7d65a1f1425f9f69c4fbec066c11 |
| 출처 메모 | uspto-grants-2013_11 |