反应详情

To a suspension of 1-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-one (0.05 g, 0.17 mmol) in methanol (50 mL) was added sodium borohydride (NaBH4) (0.01 g, 0.17 mmol) and the resulting mixture was stirred for 1 h at room temperature and then quenched with few drops of water. The solvent was removed under reduced pressure, the crude dissolved in EtOAc (5 mL) and filtered, then the organic phase was evaporated under reduced pressure to afford 0.02 g (36%) of the title compound.

1. customquenched with few drops of water
2. customThe solvent was removed under reduced pressure
3. dissolutionthe crude dissolved in EtOAc (5 mL)
4. filtrationfiltered
5. customthe organic phase was evaporated under reduced pressure