Cesium carbonate → HCID 68672005, compound

Participants

Reaction Conditions

Reaction Steps

2-(3-Bromo-phenyl)-1-difluoromethyl-1H-benzoimidazole (0.10 g, 0.31 mmol), cesium carbonate (0.14 g, 0.43 mmol), rac-2,2′ bis(diphenylphosphino)-1,1′-binaphtyl (BINAP) (0.007 g, 0.01 mmol) and tris-(dibenzilideneacetone)-dipalladium(0) (0.004 g) were placed into a 7 mL sealed vial and purged by repeated nitrogen/vacuum cycles for ten minutes. Dry toluene (0.6 mL) and N-acetylhomopiperazine (0.05 mL, 0.37 mmol) were added and reaction mixture was heated at 85° C. for 24 hours with stirring.

Provenance & Evidence