HCID 68670591, compound → HCID 68671269, compound

Participants

Reaction Steps

To a solution of 4-{4-[3-(1-Difluoromethyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carbonyl}-piperidine-1-carboxylic acid tert-butyl ester (0.075 g, 0.14 mmol) in DCM (0.5 mL), 2M HCl in Et2O (2.5 mL) was added and the resulting suspension was stirred at room temperature for 6 h. The precipitate was filtered and tritured with Et2O (3×20 mL) The solid was purified by preparative HPLC. HPLC fractions were neutralized with K2CO3 and concentrated. DCM (5 mL) and water (5 mL) were added, organic phase was separated and concentrated to give 44 mg of the title compound (72%).

Provenance & Evidence