Sodium Hydroxide → HCID 68670594, compound

Participants

Reaction Conditions

Reaction Steps

NaOH powder (0.24 g, 6.02 mmol) was added to a solution of 1-[3-(1-Difluoromethyl-1H-benzoimidazol-2-yl)-phenyl-]piperidine-4-carboxylic acid ethyl ester (1.20 g, 3.01 mmol) in ethanol:water 3:1 and the reaction was heated at 80° C. overnight. Reaction was cooled to room temperature and the organic solvent concentrated by evaporation under reduced pressure. The resulting solution was neutralized by dropwise addition of 6N HCl. A pale brown precipitated and it was filtered off and dried to afford 0.80 g of the title compound (72%).

Provenance & Evidence